Thursday, 16 May 2013

Protecting the health care rights of pregnant women

The AMA has released its Position Statement on Maternal Decision-Making.

The Position Statement highlights the AMA’s policy on maternal decision-making, where a pregnant woman has the same right to privacy, body integrity, and to make her own informed, autonomous health care decisions as any competent individual.

AMA President, Dr Steve Hambleton, said that the AMA promotes a positive, supportive and collaborative approach to health care, where patients are supported in making their own informed health care decisions.

“Doctors play an important role in supporting pregnant women to make fully informed health care decisions by providing advice on the risks and benefits to both the woman and the fetus of lifestyle and medical treatment options,” Dr Hambleton said.

“A pregnant woman’s fully informed health care decision regarding lifestyle behaviours and medical treatment should be respected.”


(Source: Australian Medical Association : Position Statement on Maternal Decision-Making)

PregnancyFor more information about pregnancy, including preconception advice, stages of pregnancy, investigations, complications, living with pregnancy and birth, see Pregnancy.

calendar icon Article Date: 28/4/2013
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Non-Medically Indicated Delivery Prior To 39 Weeks In United States Hospitals


Non-Medically Indicated Delivery Prior To 39 Weeks In United States Hospitals

A national movement to eliminate non-medically indicated (NMI) delivery before 39 weeks has prompted nearly two-thirds of all U.S. hospitals handling non-emergency births to adopt specific policies against the practice, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The results of the nationwide survey represent a strong step in promoting maternal and perinatal health, and reducing the number of infants requiring admission to the neonatal intensive care unit (NICU). The full results of the survey were presented at the Annual Clinical Meeting of the American College of Obstetricians and Gynecologists.

Historically, babies born 37 weeks into gestation were considered "full term" and were thought to have the same risk of complication as those born at 38 or 39 weeks. However, recent data demonstrates that babies born at 37 or 38 weeks actually have higher complication rates than those delivered at 39 weeks. These babies born "near term" tend to have higher rates of respiratory distress syndrome and other complications requiring admission to the NICU.


As a result of the increased risk, ACOG has issued guidelines recommending that NMI delivery not be performed prior to 39 weeks gestation, as determined by appropriate pregnancy dating criteria. Though there has been a nationwide movement, including many state-wide initiatives, to increase awareness about the harm that NMI deliveries can cause, these elective early deliveries continue to occur.


"Our results show that most hospitals do recognize the issues with early elective delivery, or non-medically indicated delivery prior to 39 weeks, and are adopting policies to prevent the practice," said Nathaniel G. DeNicola, MD, Robert Wood Johnson Clinical Scholar at the Perelman School of Medicine at the University of Pennsylvania, and lead author on the study. "State quality collaboratives and guidelines represent effective tools in raising awareness and promoting hospital policy adoption. However, variability still exists and barriers to compliance with ACOG guidelines are not well defined. These inconsistencies allow for flexible interpretation on how these hospital policies should be structured."


Researchers contacted all U.S. hospitals - including Washington DC and - with a registered labor and delivery unit (n = 2,641) to determine, via telephone interview with a nurse or nurse manager, the hospital's specific policy regarding timing of NMI delivery. The goal of the survey was to detail each hospital's policy, what type of policy exists, and the regions in greatest need of targeted intervention. Of the responding hospitals (n = 2,367), the majority (66.5 percent) reported having a formal policy in place against the practice, and 33.5 percent reported no policy. Of the hospitals without a formal policy, 53 percent said that NMI deliveries are against their standard of care. Of the hospitals with a formal policy, 69 percent said they had a "hard-stop" policy, a strictly enforced hospital policy against NMI deliveries less than 39 weeks.


DeNicola says the survey results show regional differences among states as a strong contributing factor to policy variation among hospitals. Policy variation, he says, may be explained by several influences such as regionalized practice norms within medicine, local hospital alliances, and state quality collaboratives. Further investigation into the states that have effective quality collaboratives may serve as useful models for states or regions that have not yet seen widespread adoption of NMI policies.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pregnancy / obstetrics section for the latest news on this subject. Poster #50
The study was funded by the Leonard Davis Institute on Health Economics, the Department of Veterans Affairs, and the Robert Wood Johnson Foundation. In addition to Dr. DeNicola, Penn Medicine experts include Andrew J. Epstein, PhD, MPP, research associate professor of Medicine, and Sindhu Srinivas, MD, MSCE, assistant professor of Obstetrics and Gynecology.
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Taking Valproate While Pregnant Raises Autism Risk


Researchers have found that pregnant women who take the drug valproate (for epilepsy) could be at an increased risk of giving birth to a child with autism, according to a new study published in the journal JAMA.

Valproate is also prescribed for migraine, panic attack, anorexia nervosa, anxiety disorder, posttraumatic stress disorder, bipolar disorder, as well as some other psychiatric conditions.


The background information of the article said: "Anti-epileptic drug exposure during pregnancy has been associated with an increased risk for congenital malformations and delayed cognitive development in the offspring, but little is known about the risk of other serious neuropsychiatric disorders."


The U.S. Food and Drug Administration has already issued a warning concerning the risks of taking valproate while pregnant. They stated that there are already studies that have found that children of mothers who took valproate sodium while pregnant have a higher risk of lower cognitive test scores compared to those whose were exposed to different anti-seizure medications.


In this study the researchers conducted a population based study to see whether the maternal use of the drug valproate during pregnancy had any association with an increased risk of autism in the offspring. Jakob Christensen, Ph.D., of Aarhus University Hospital, Aarhus, Denmark, led a team which analyzed Danish children born between 1996 and 2006.


They gathered data from national registers to see how many children were exposed to the drug valproate as well as how many were diagnosed with an autism-spectrum disorder.


A total of 655,615 children born from 1996 through 2006 were included in the study, of whom 5,437 were diagnosed with an autism spectrum disorder.


The children were followed until the day they were diagnosed with autism, death or December 31, 2010. They adjusted the data for factors that could influence outcomes (such as maternal age at conception and prevalence of mental illness in the family).


Of the 2,644 children who were found to be exposed to antiepileptic drugs during pregnancy 508 were specifically exposed to the drug valproate.


They found that the children exposed to valproate were at a 4.42 percent risk of an autism spectrum disorder as well as a 2.50 percent risk of childhood autism.


Although valproate is a very effective drug, prescribing it to pregnant women should be minimized. Instead, doctors should offer alternative therapies. If no alternative therapies work, then only the lowest effective dose of valproate should be prescribed. Those who have to take it should be fully aware of the risks involved of taking the medication.


The American Academy of Neurology and the American Epilepsy Society have both said that while it's safe for women with epilepsy to become pregnant, particular caution must be taken with valproate. The authors of the study concluded:


"In this population-based cohort study, children of women who used valproate during pregnancy had a higher risk of autism spectrum disorder and childhood autism compared with children of women who did not use valproate. Their risks were also higher than those for children of women who were previous users of valproate but who stopped before their pregnancy.

Because autism spectrum disorders are serious conditions with lifelong implications for affected children and their families, even a moderate increase in risk may have major health importance. Still, the absolute risk of autism spectrum disorder was less than 5 percent, which is important to take into account when counseling women about the use of valproate in pregnancy."

Written by Joseph Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our autism section for the latest news on this subject. "Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism"
Jakob Christensen, PhD; Therese Koops Grønborg, MSc; Merete Juul Sørensen, PhD; Diana Schendel, PhD; Erik Thorlund Parner, PhD; Lars Henning Pedersen, PhD; Mogens Vestergaard, PhD
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All Adults, Adolescents, And Pregnant Women Should Be Screened For HIV


New recommendations from the United States Preventive Services Task Force (USPSTF) urge physicians to screen all adults and adolescents aged 15 - 65 for HIV. In addition, all pregnant women should receive screening, even those who are in labor but have not yet been screened. Rapid screening tests and conventional tests are considered equally accurate for screening.

In 2005, the Task Force recommended that doctors offer HIV screening to all adults and adolescents at increased risk for infection (men or women having a blood transfusion from 1978 to 1985; men or women having unprotected sex with multiple partners; men who have had sex with men after 1975; men and women who have exchanged sex for money or drugs, or who have sex partners who have done so; men or women whose past or present sex partners were HIV-infected, bisexual, or intravenous drug users; and men or women with other sexually transmitted diseases).


For patients with no risk factors, the Task Force recommended that doctors discuss the benefits and harms of testing. For pregnant women, the Task Force recommended HIV screening at their initial prenatal visit unless they specifically decline testing. Since then, the Task Force reviewed the literature for new studies, specifically those focusing on key research gaps identified in the earlier evidence review. A significant difference since 2005 is that researchers reviewed the data to assess the benefits and harms associated with universal screening. The research showed that screening for HIV infection improves clinical outcomes versus no screening, and is associated with very little risk for harm. In contrast, targeted screening misses a substantial number of HIV cases due to undisclosed or unknown risk factors. HIV screening in pregnant women dramatically reduces rates of mother-to-child transmission.


The full recommendation will be posted here.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our hiv / aids section for the latest news on this subject. Annals of Internal Medicine April 30, 2013
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Wednesday, 15 May 2013

In Adolescents, Intervention Can Prevent Postpartum Depression


By targeting the factors that may play a significant role in the development of postpartum depression (PPD) in adolescent mothers, researchers at Women & Infants Hospital of Rhode Island believe they have found a way to prevent it.

The team - led by Maureen G. Phipps, MD, MPH, interim chief of obstetrics and gynecology and director of the Division of Research at Women & Infants, and Caron Zlotnick, PhD, of the hospital's Center for Women's Behavioral Health - recently published "Randomized controlled trial to prevent postpartum depression in adolescent mothers" in the American Journal of Obstetrics and Gynecology.


"Postpartum depression puts adolescent mothers and their children at risk in an already challenging time in their lives," Dr. Phipps explains. "This hardship may be a major determinant of poor outcomes for these young mothers and their children. Untreated, depression is associated with school dropout, suicide and substance abuse."


In addition, Dr. Phipps says adolescents who are depressed do not tend to focus on their baby's health or their own.


"Overall, children who are born to mothers with untreated depression show higher rates of developmental delays, lower levels of social engagement, increased stress reactivity, and negative interactions as compared with children of mothers who are not depressed," she adds.


Most teenage mothers with mental health problems are currently undertreated. The research team sought to test the effectiveness of an intervention called REACH (Relaxation, Encouragement, Appreciation, Communication, Helpfulness), adapted from an interpersonal therapy-based prevention intervention that had been found to reduce PPD in adults.


For this study, pregnant girls up to age 18 were recruited through Women & Infants' Womens Primary Care Center in 2007 and 2008. Half were enrolled in the REACH program, an intervention delivered over five one-hour sessions during pregnancy and one postpartum session that includes multimedia, interactive components, and homework with feedback. The other participants were part of the study's control group.


"REACH is designed to help the girls develop effective communication skills so they can manage relationship conflicts before and after the baby's birth, know what to expect from motherhood, manage stress, differentiate 'baby blues' from depression, develop a support system and healthy relationships, and set goals," Dr. Phipps says.


When all of the babies had been delivered and the postpartum visits were complete, researchers found that the incidence of PPD was 50% lower for the mothers in the REACH program compared with those in the control group.


"We believe this is the first clinical trial to prevent PPD in adolescent mothers and we are excited to report that the results show a positive trend supporting the interpersonal-based intervention program," Dr. Phipps says.


"With further evaluation, the REACH program has the potential to decrease disease burden for adolescent mothers and their children and to be a cost-effective alternative to the treatment of PPD."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Home Births - AAP Issues Guidelines


As the rate of home births continues to rise in the U.S., the American Academy of Pediatrics (AAP) released a new policy statement published in the journal Pediatrics, titled "Planned Home Birth", which includes a number of new recommendations for the care of children born at home. In particular, it stated that there should be at least one person assigned to always be present to care for the newborn.

Only one percent of all births in the United States are carried out at home, However, over recent years the rate has been climbing. According to the U.S. Centers for Disease Control and Prevention, between 2004 and 2008 there was a 20 percent increase in the number of home births.


Women often want to give birth at home because it provides a family setting, as well as being cheaper and involves fewer medical interventions.


Home births are not encouraged by medical experts, who are concerned that home is not the ideal setting in case of an emergency, especially if travel times for medical care to arrive are long.


According to research published in the American Journal of Obstetrics & Gynecology, a home-birth-similar experience in the hospital proves to be more financially feasible, safer, and more satisfying than an actual at-home birth.


Newborns, no matter the circumstance of their birth, should always receive health care standards that adhere to the AAP. The AAP has already stated that the safest environment for a baby to be born in is either a hospital or birthing center. However, the academy understands that some women may wish for their child to be born at home.


In fact, a previous editorial in the medical journal The Lancet stated that while a woman has the right to choose where and how to give birth, she does not have the right to put her baby at risk.


In contrast, another study by researchers in Canada at McMaster University revealed that low-risk women giving birth with the assistance of midwives have positive outcomes regardless of where the delivery takes place.


Lead author of the statement, Dr. Kristi Watterberg, said: "Babies deserve the best care they can get. And we need to support women wherever they choose to give birth."


The AAP recommends parents who want to go through with a home birth carefully choose midwives who have been certified by the American Midwifery Certification Board.


In addition, there should be at least one person present during and after delivery who specializes in caring for the newborn infant. They should have the necessary training and equipment to perform full resuscitation if required.


Before delivery, it's crucial that all medical equipment is tested as well as making sure that there is a way to call in case of an emergency.


The AAC recommends that pregnant women considering home birth should: Have no preexisting medical conditionsBe pregnant for at least 37 weeks and no more than 41 weeksHave access to consultation with a healthcare professionalMake sure that a trained professional cares for the newborn and attends to any medical emergencies if necessaryEnsure that there is available transport to a nearby hospitalWatterberg added:

"It's important to remember that this is an area of strong emotion. You'll see babies in home births have terrible things happen, but you also have terrible things happen in the hospital sometimes. Women have the right to make an informed decision."

The authors concluded:


"The goal of providing high-quality care to all newborn infants can best be achieved through continuing efforts by all participating health care providers and institutions to develop and sustain communications and understanding on the basis of professional interaction and mutual respect throughout the health care system."

Written by Joseph Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our pregnancy / obstetrics section for the latest news on this subject. ”Planned Home Birth - Policy Statement”
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High Celiac Disease Antibodies During Pregnancy Increase Risk For Low Birth Weight Babies


Pregnant women with mid to high levels of antibodies common in patients with celiac disease are at risk for having babies with reduced fetal weight and birth weight, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. The antibody tissue transglutaminase (anti-tTG) is most commonly found in patients with celiac disease.

"While several observational studies have suggested that celiac disease is associated with different pregnancy outcomes, this research takes into account the actual levels of tissue transglutaminase that reflect the degree of mucosal damage associated with undiagnosed celiac disease or limited compliance to a gluten-free diet. This differentiation is critical since most celiac disease cases remain undiagnosed," said Jessica Kiefte-de Jong, MSc, Erasmus University Medical Center, and lead author of the study.


Researchers conducted a population-based perspective birth cohort study of 7,046 pregnant women, and categorized subjects into three groups: negative anti-tTG (control), intermediate anti-tTG (just below the clinical cut-off point used to diagnose patients with celiac disease) and positive anti-tTG (highly probable celiac disease patients). Fetuses of women with positive anti-tTG weighed 16 grams less than those of women with negative anti-tTG levels during the second trimester and weighed 74 grams less during the third trimester.


People with intermediate anti-tTG levels are generally not considered to be potential celiac disease patients, yet birth outcomes for these individuals were also affected. Infants of women with intermediate and positive anti-tTG weighted 53 grams and 159 grams less at birth, respectively, than those of women with negative anti-tTG.


"Researchers need to explore the natural history and long-term consequences of intermediate anti-tTG levels to determine if these levels are caused by pregnancy or whether it reflects a subclinical state of celiac disease that needs follow-up," added Jong.


Further helping to identify the connection between anti-tTG levels and celiac disease, a study in Clinical Gastroenterology and Hepatology reconfirms the recent European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines, which recognize that the likelihood for celiac disease increases with increasing antibody concentration.


Research from University Hospitals Leuven, Belgium, stresses the importance of also monitoring for relevant symptoms, such as weight loss, failure to thrive, anemia, iron deficiency or fatigue, when diagnosing patients, and notes that physicians should not rely solely on anti-tTG testing to make a diagnosis.


The study found that there is a 50 to 75 percent chance that persons without symptoms, but with anti-tTG levels more than 10 times the cutoff value, as defined in the ESPGHAN guidelines, will have celiac disease. The probability that a patient has celiac disease rises to 95 percent or higher when, in addition to high anti-tTG levels, the patient expresses complaints that can be associated with celiac disease.

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Mild Iodine Deficiency During Pregnancy Can Harm The Baby's Neurological Development


Mild Iodine Deficiency During Pregnancy Can Harm The Baby's Neurological Development

Children who did not receive enough iodine in the womb performed worse on literacy tests as 9-year-olds than their peers, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Iodine is absorbed from food and plays a key role in brain development. Even mild deficiency during pregnancy can harm the baby's neurological development.


"Our research found children may continue to experience the effects of insufficient iodine for years after birth," said the study's lead author, Kristen L. Hynes, PhD, of the Menzies Research Institute at the University of Tasmania in Australia. "Although the participants' diet was fortified with iodine during childhood, later supplementation was not enough to reverse the impact of the deficiency during the mother's pregnancy."


The longitudinal study examined standardized test scores of 228 children whose mothers attended The Royal Hobart Hospital's antenatal clinics in Tasmania between 1999 and 2001. The children were born during a period of mild iodine deficiency in the population. Conditions were reversed when bread manufacturers began using iodized salt in October 2001 as part of a voluntary iodine fortification program.


The study found inadequate iodine exposure during pregnancy was associated with lasting effects. As 9-year-olds, the children who received insufficient iodine in the womb had lower scores on standardized literacy tests, particularly in spelling. However, inadequate iodine exposure was not associated with lower scores on math tests. Researchers theorize iodine deficiency may take more of a toll on the development of auditory pathways and, consequently, auditory working memory and so had more of an impact on students' spelling ability than their mathematical reasoning ability.


"Fortunately, iodine deficiency during pregnancy and the resulting neurological impact is preventable," Hynes said. "Pregnant women should follow public health guidelines and take daily dietary supplements containing iodine. Public health supplementation programs also can play a key role in monitoring how much iodine the population is receiving and acting to ensure at-risk groups receive enough iodine in the diet."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pregnancy / obstetrics section for the latest news on this subject. The Endocrine Society's clinical practice guidelines on managing thyroid dysfunction during pregnancy and postpartum, including iodine supplementation, are available at http://www.endo-society.org/guidelines/upload/Thyroid-Exec-Summ.pdf.

Other researchers working on the study include: P. Otahal, I. Hay and J. Burgess of the University of Tasmania.


The article, "Mild Iodine Deficiency During Pregnancy is Associated with Reduced Educational Outcomes in the Offspring: 9-Year Follow-Up of the Gestational Iodine Cohort," appears in the May 2013 issue of JCEM.


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More Infants Surviving With Serious Heart Defects, Study Finds

News Picture: More Infants Surviving With Serious Heart Defects, Study FindsBy Kathleen Doheny
HealthDay Reporter

THURSDAY, April 25 (HealthDay News) -- Babies born with serious congenital heart defects are more likely to survive now than they were in the late 1970s, a new study finds. There is still plenty of room for improvement, however, the researchers added.

Over a 26-year period, they tracked the percentage of children born with the most serious heart defects who survived the one-year mark.

"For infants with a critical congenital heart defect, survival up to one year has improved over time," said researcher Dr. Matthew Oster, medical officer at the U.S. Centers for Disease Control and Prevention.

"It has improved from 67 percent at one year for infants born from 1979 to 1993 to 83 percent for those born from 1994 to 2005," he said.

One of every 110 births in the United States involves a congenital heart defect, the researchers said. Some are known as non-critical, not needing immediate attention. The more serious defects are known as critical congenital heart defects (CCHDs). For this study, Oster's team focused only on these most serious defects.

About one of four heart defects are CCHDs. One example is a condition known as hypoplastic left heart syndrome, in which the left side of the heart, including the left ventricle, doesn't develop properly.

During the period studied, more than 1 million babies were born, including 7,000 with a congenital heart defect. Of those, nearly one-fourth had a CCHD. The data was obtained from the Metropolitan Atlanta Congenital Defects Program.

The study was published online April 22 and in the May print issue of the journal Pediatrics.

Children diagnosed with CCHDs at one day old or earlier had a lower survival rate (72 percent) than those diagnosed after one day of age (83 percent), Oster found. The researchers suspect that is because they had a more severe defect that was recognized more quickly. The earlier children were born during the 26-year time period, the lower the survival rate. Those whose mothers were under the age of 30 also were less likely to survive the one-year mark.

The study is an important one, said Dr. Edward McCabe, medical director of the March of Dimes.

Although the study showed that "things are getting better," McCabe said, more improvement is needed. Nearly one in five do not live until their first birthday. "That's a concerning public health issue," he said.

The study also has another purpose, besides documenting whether survival has improved. It will provide a kind of baseline for researchers to look at as they assess the effectiveness of a screening test, called pulse oximetry, that is being used increasingly to diagnose these defects.

In 2011, screening for CCHDs was added to the recommended list of newborn health conditions to check for by the U.S. Secretary of Health and Human Services.

Pulse oximetry, already available and used for other patients, is noninvasive and done at the bedside. The test costs about $10.

A probe placed on the baby's foot detects the percent of hemoglobin saturated with oxygen. Babies with CCHDs usually have a low percent of saturation even before symptoms appear.

The latest findings will provide important information so researchers can evaluate how much of a difference the pulse oximetry screening will make in earlier diagnosis and improved survival going forward, McCabe said.

Meanwhile, expectant parents, especially those with a family history of heart defects, should ask their health care provider if they are planning to do pulse oximetry testing, McCabe said. Many times, he said, the defects can even be detected before birth.

MedicalNews
Copyright © 2013 HealthDay. All rights reserved. SOURCES: Matthew Oster, M.D., medical officer, U.S. Centers for Disease Control and Prevention, Atlanta; Edward McCabe, M.D., Ph.D., medical director, March of Dimes; May 2013 Pediatrics



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Concern over new immunisation rate data

Australian Academy of Science President, Professor Suzanne Cory expressed grave concern over reports today rates of immunisation are so low in some areas of Australia that there is a risk that contagious diseases will spread.

The National Health Performance Authority report revealed that while Australia has high immunisation rates by world standards, more than 77,000 Australian children have not been immunised.

"It's concerning that so many children remain unprotected," Professor Cory said.

"When people are not immunised, they risk exposing young babies - who cannot be immunised - to life-threatening diseases such as measles and whooping cough.

"In the case of a highly infectious disease such as measles, more than 95 per cent of the population must be vaccinated to achieve sufficient level of immunity to prevent transmission if the disease recurs.

"The Academy is concerned that low rates of immunisation persist in Australia because of misinformation and misunderstanding about immunisation science."

The Australian Academy of Science recently set out to counter misinformation about immunisation and put to rest some common myths with a comprehensive booklet written by the nation's top immunologists.

The Science of Immunisation: Questions and Answers explains the latest immunology science in accessible language, in response to confusion created by contradictory information in the public domain.

Professor Cory urged all parents to use it as an aid to making crucial decisions about their children's health.

"The Academy is strongly committed to ensuring that every Australian has the opportunity to understand scientific issues and base their decisions on the best available evidence," Professor Cory said.

"That's why we brought together some of the best researchers in the field in Australia to develop a document written as simply as possible, and which is thorough and scientifically rigorous."

Since its launch in November, more than one million copies of the booklet have been distributed in hardcopy or downloaded from the Academy's website.


(Source: Australian Academy of Science : The Science of Immunisation: Questions and Answers)

Immunisation (immunization)For more information on immunisation, including the childhood immunisation scedule, types of vaccines, preconception screening, as well as some useful videos, see Immunisation.
calendar icon Article Date: 28/4/2013
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Tuesday, 14 May 2013

Pediatrician Group Issues Home Birth Policy Statement

News Picture: Pediatrician Group Issues Home Birth Policy StatementBy Serena Gordon
HealthDay Reporter

MONDAY, April 29 (HealthDay News) -- With the number of home births rising, the American Academy of Pediatrics has issued a policy statement on the practice that includes a recommendation that there be a caregiver who's present solely to take care of the newborn.

"Babies deserve the best care they can get," said Dr. Kristi Watterberg, lead author of the statement and a professor in the division of neonatology at the University of New Mexico. "And we need to support women wherever they choose to give birth."

There are a number of reasons women may choose to give birth at home, according to background information in the statement. They may wish for a more family-friendly setting, increased control of the birthing process, fewer medical interventions and lower costs. The rate of home births is still under 1 percent in the United States, but it is growing, according to the policy statement.

A recent report from the U.S. Centers for Disease Control and Prevention found that the number of home births jumped 20 percent between 2004 and 2008. More than 28,000 babies were born at home in 2008, which was the highest number of home births since 1990.

Home births aren't well supported by the medical community. Various state laws and regulations can make a home birth even harder to achieve. There also may be a lack of well-trained and willing caregivers, or support in case of an emergency. Geography can also present a problem. Travel times greater than 20 minutes to medical care have been linked to an increased risk of complications, including death of the baby, according to the policy.

Some studies have suggested that home births in the United States are linked to a twofold to threefold higher risk of neonatal death. But Watterberg said a study done in British Columbia, where there's a more integrated system that supports mothers birthing at home, found no increased risk of neonatal death. "We need better research," said Watterberg.

However, because the rate of home births is increasing, and because the academy wants to provide a "professional, supportive interaction" with expectant mothers, Watterberg said the group developed its new policy. The AAP recommends the following factors for a mother considering a home delivery:

Absence of preexisting medical conditions,Absence of significant disease during pregnancy,A singleton pregnancy (no twins, triplets or higher), Baby's head is facing down,Pregnancy has lasted at least 37 weeks, but no more than 41 weeks,Spontaneous labor, or labor induced as an outpatient,A certified nurse-midwife, certified midwife or a physician practicing within an integrated and regulated health system,At least one appropriately trained person whose primary responsibility is the baby (this person must be qualified to resuscitate the baby if necessary), Ready access to consultation,Assurance of safe and timely transport to a nearby hospital with a preexisting arrangement for such transfers.

Watterberg said midwives often work in teams, and one can be responsible for the baby's care after birth.

"It's important to remember that this is an area of strong emotion. You'll see babies in home births have terrible things happen, but you also have terrible things happen in the hospital sometimes. Women have the right to make an informed decision," she said.

And, if a woman chooses home birth, Watterberg said it's important for the expectant mother to meet the person who will care for her baby after birth. "Meet with that person beforehand. Talk with them about your plans, and see if they have anything to add," she advised.

Dr. Peter Bernstein is a maternal-fetal medicine specialist and director of the perinatal safety program at Montefiore Medical Center in New York City. He said: "A woman planning a home birth has a lot of due diligence to take care of that she doesn't have to worry about in the hospital, like making sure the correct equipment is there, that the staffing is there and qualified.

"I understand where women are coming from. A hospital birth can become very medicalized and women feel a loss of control, but I'm nervous about home births. Too many simple things can turn into disasters at home. Even in low-risk women, things can go wrong. Then you may be 20 minutes from the hospital, and it's another 15 minutes once you get to the hospital before you can get the baby out in an emergency," explained Bernstein, who acknowledged that he treats high-risk pregnancies, so he tends to see more complicated births.

"I'd like to see a middle ground. I'd like to see more birthing centers associated with hospitals. Bring the home birth movement to a setting that feels more like home, but is attached to the hospital," he said.

But, he added, "In a low-risk woman, who can set it up properly, home birth shouldn't be outlawed. A woman can have the choice to have her baby at home."

The full policy statement is published online April 29 and will appear in the May print issue of the journal Pediatrics.

MedicalNews
Copyright © 2013 HealthDay. All rights reserved. SOURCES: Kristi Watterberg, M.D., professor, division of neonatology, University of New Mexico, Albuquerque; Peter Bernstein, M.D., MPH, maternal-fetal medicine specialist, and director, perinatal safety program, Montefiore Medical Center, New York City; May 2013, Pediatrics



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Keep Beauty Regimen Safe During Pregnancy, Doctor Advises

News Picture: Keep Beauty Regimen Safe During Pregnancy, Doctor Advises

TUESDAY, April 30 (HealthDay News) -- For the many pregnant women who are concerned about how beauty products, such as hair dyes and skin creams, will affect their developing baby, an expert offers some advice on what is safe.

"Women face a lot of uncertainty as their bodies change during pregnancy, and many worry about how to look their best," Dr. Mary Rosser, of the department of obstetrics and gynecology and women's health at Montefiore Medical Center, said in a Montefiore news release.

"We work hard to separate truth from fiction to put mothers at ease and help them figure out ways to make this special time in their lives consistent with the way they're used to living and looking," Rosser explained.

Women should try to avoid using hair dyes during pregnancy, she advised. Pregnant women who want to color their hair should do so after the first trimester and in a well-ventilated space. Women should tell their hair stylist that they are pregnant and ask them to try to prevent the chemicals from touching their scalp, Rosser noted.

The main concern with hair dyes is breathing the ammonia fumes that could be harmful to the developing baby in the first three months of pregnancy. The fumes in hair straightening products are also an issue, she said.

Highlights are considered safer because the dye is enclosed in foil and won't be absorbed into the skin. Rosser added that vegetable dyes such as henna are likely the safest choice during pregnancy.

Pregnant women can get a standard manicure after the first trimester, when the risk to the developing baby is lower. Check that the instruments have been sterilized and ask the nail technician not to cut the cuticles. This will prevent exposure to germs, according to Rosser, who is also an assistant professor in the department of obstetrics and gynecology and women's health at Albert Einstein College of Medicine of Yeshiva University, in New York City.

Pregnant women should avoid acrylic nails. The chemicals and adhesives can contain cyanoacrylate, which can be harmful. This substance can be inhaled in the dust when nails are filed, so wear a mask and make sure there is proper ventilation in the nail salon, Rosser suggested.

Pregnant women with acne should wear oil-free cosmetics and wash their face twice a day with a gentle cleanser and lukewarm water. If acne persists, ask your doctor for a prescription for erythromycin. Do not use Retin A or tetracycline, which can cause birth defects, Rosser warned.

Wearing sunscreen can prevent dark circles around the eyes and darkening pigment of the skin. Rubbing vitamin E on the areas most likely to be affected by stretch marks may be helpful, she noted.

"The most important thing to remember is that this is a happy time in your life and you are beautiful just by nature of being a pregnant woman," Rosser said. "As long as you make smart choices, get plenty of rest, drink lots of water and eat a healthy, balanced diet, you can enjoy your pregnancy, look and feel good, and have a healthy baby!"

-- Robert Preidt MedicalNews
Copyright © 2013 HealthDay. All rights reserved. SOURCE: Montefiore Medical Center, news release, April 25, 2013



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Disease connection discovery could point to better health

New research revealing links between two global health challenges – depression and chronic lung disease – suggest screening for both disorders simultaneously could improve outcomes for patients.

The study by Senior Research Fellow Dr Evan Atlantis(opens in new window) from the University of Western Sydney, and colleagues, found patients with diagnosed chronic obstructive pulmonary disease (COPD) who also had depression or anxiety consistently had worse outcomes including increased mortality.

The researchers report in CHEST - the online journal of the American College of Chest Physicians(opens in new window) COPD patients with comorbid depression had an 83 percent increased risk of mortality.

Additionally, COPD patients had a much higher chance of also being diagnosed with depression. Forty percent of COPD patients had clinically relevant depression and anxiety compared to less than 10 percent in the general population across most countries surveyed.

The researchers analysed data from longitudinal studies in adult populations that reported an association between clinically relevant depression or anxiety and COPD, or reported their combined risk for having an exacerbation (a serious worsening of COPD) and/or dying.

“It’s clear from the studies we reviewed that depression and anxiety adversely affect prognosis for COPD patients and COPD patients have a greater likelihood of having depression or anxiety compared to the general population,” says Dr Atlantis, who is a member of the UWS School of Nursing and Midwifery’s Family and Community Health Research Group(opens in new window).

“Screening for these disease combinations would identify patients with both COPD and depression/anxiety and provide clinicians the opportunity to treat both problems at the same time - potentially delivering a better overall health outcome.”

Depression or anxiety comorbidity in COPD patients predict poor adherence to pulmonary rehabilitation and COPD-related medications, decreased exercise capacity and health-related quality of life.  There is also lost productivity and increased health resource utilisation and functional disability and increased risk of exacerbation and mortality.

“Currently about 10 percent of the world’s population aged 40 years and older have COPD,” says Dr Atlantis.

“COPD rates increase with age, independently of smoking history.  So, an aging world population will increase the rates of COPD and undoubtedly cause significant stress on healthcare systems in high-income countries, and may threaten economic growth in developing countries.”

More information: Bidirectional associations between clinically relevant depression or anxiety and chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis(opens in new window) Evan Atlantis, PhD; Paul Fahey, MMedStat; Belinda Cochrane, MD; Sheree Smith, PhD
CHEST. 2013 doi:10.1378/chest.12-1911

(source: University of Western Sydney)


calendar icon Article Date: 1/5/2013
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Tobacco smoke harms teenage kidneys

The kidneys of children may be harmed by exposure to secondhand smoke in childhood - reducing their capacity to filter out poisons, says a new study.

Action on Smoking and Health (ASH) Australia has called for greater protection of children – including parents making smokefree homes the norm; all outdoor eating and drinking areas being smokefree; and federal regulation of tobacco products to make them less palatable and addictive.

The kidneys of children may be harmed by exposure to secondhand smoke in childhood - reducing their capacity to filter out poisons, says a new study.

Action on Smoking and Health (ASH) Australia has called for greater protection of children – including parents making smokefree homes the norm; all outdoor eating and drinking areas being smokefree; and federal regulation of tobacco products to make them less palatable and addictive.

The US study* of over 7,500 children aged 12-17 showed both active smoking and exposure to secondhand smoke reduced their kidneys’ ability to filter and eliminate toxins in the body. The authors concluded their findings supported “the possibility that tobacco smoke effects on kidney function begin in childhood.”

Says Anne Jones, ASH Chief Executive: “One in three Australians is at increased risk of developing chronic kidney disease – and smoking has been long known to be a risk factor.

“More than 100,000 school-aged Australian kids are already smoking regularly – and this new study shows that even before becoming a smoker, children may be suffering kidney harm by inhaling the smoke of others.

“We also know from surveys that many thousands of children are routinely exposed to secondhand smoke in their own homes – not just from smokers at home but also from smoke drift that is a common complaint from non-smokers living in multi-unit blocks.

“Although there is a growing trend for crowded outdoor areas to be smokefree, we still have smoking permitted in outdoor and partly enclosed dining areas in South Australia, Victoria, NSW and in half of the outdoor dining areas in WA.  

“Tobacco products are highly engineered nicotine delivery devices that have been made more palatable to attract new smokers who are mostly children. We can do a lot more to reduce the number of children harmed by tobacco products if we require the manufacturers to make the contents less palatable and addictive.

“We welcome yesterday’s announcement of the new anti-smoking campaign by the federal government, ‘Stop before the suffering starts’. But we still need more coordinated efforts by governments and parents to protect children from highly engineered addictive tobacco products that kill 15,000 Australians every year.”

(source: ASH Australia)


calendar icon Article Date: 28/4/2013
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Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced


When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound. But a new study from the Stanford University School of Medicine and Lucile Packard Children's Hospital shows anesthesia is cost-effective because it increases the likelihood the procedure will work.

The turning procedure, called an external cephalic version, or simply a "version," can allow some women with breech babies to avoid a cesarean section and have a head-first vaginal delivery instead. Prior studies have shown that spinal or epidural anesthesia - similar to the anesthetic techniques offered during childbirth - can help more babies to be turned successfully. Many obstetricians still do not use anesthesia when doing a version.


"We've been looking at reasons physicians don't offer anesthesia during this procedure, and one reason may be that they think it may add extra costs," said the study's lead author, Brendan Carvalho, MD, associate professor of anesthesia at Stanford and chief of obstetric anesthesia at Packard Children's. "But our work shows that it doesn't add significant costs, and most likely reduces overall costs because more women can avoid cesareans."


The study was published online in Anesthesia & Analgesia.


Because a breech vaginal delivery, in which a baby is born feet-first or bottom-first, is more dangerous for the mother and baby than a head-first vaginal delivery, many breech babies are delivered by cesarean section. But cesarean sections have their own disadvantages, such as increased risk of maternal hemorrhage, more pain and longer recovery times for the mother after birth, as well as higher hospital costs. As part of their effort to reduce cesarean rates, Packard Children's obstetric anesthesiologists have been offering anesthesia during version procedures for the last two years, making Packard Children's a Bay Area leader in studying and providing anesthesia for versions.


The new research drew upon data from several earlier studies that compared version success rates with and without anesthesia. The scientists also used national data on the cost of the version procedure with and without anesthesia, and the costs of vaginal and cesarean deliveries. All of the data was entered into a mathematical model that allowed the scientists to predict whether anesthesia use during a version was cost-effective.


The study found that using anesthesia increased average success rates of version procedures from 38 percent to 60 percent. Because it led to fewer cesareans, use of anesthesia also decreased the total cost of delivery by an average of $276; the range of cost differences estimated by the model extended from a $720 savings to a $112 additional cost.


Looking at the question of cost-effectiveness in a different way, the success rates of versions had to be improved at least 11 percent with anesthesia for the cost of the anesthesia to be negated, the researchers calculated.


Prior research has also shown that women are happier with version procedures when they receive anesthesia, Carvalho noted. "The pain of this procedure is variable, but it certainly is uncomfortable," he said. "If you have anesthesia, you feel pressure more than pain. Several studies have shown lower pain scores and higher patient satisfaction with anesthesia."


Abdominal muscle relaxation likely contributes to the higher success rates of the procedures performed with anesthesia, Carvalho said, adding that muscle relaxation caused by anesthesia may allow practitioners to apply less pressure to turn the baby. A previous study by these investigators demonstrated that anesthesia does not increase the risk of performing a version.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pregnancy / obstetrics section for the latest news on this subject. Carvalho's collaborators at Stanford included Alex Macario, MD, professor of anesthesia, and Yasser El-Sayed, MD, professor of obstetrics and gynecology. Researchers from Stony Brook University in Stony Brook, N.Y., and University College London Hospital also contributed to the study.
There was no outside funding for the research.
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Exposure To Flame Retardants During Pregnancy May Damage Developing Fetus


Chemicals called polybrominated diphenyl ethers (PBDEs) have been used for decades to reduce fires in everyday products such as baby strollers, carpeting and electronics. A new study presented on Monday, May 6, at the Pediatric Academic Societies (PAS) annual meeting shows that prenatal exposure to the flame retardants is associated with lower intelligence and hyperactivity in early childhood.

"In animal studies, PBDEs can disrupt thyroid hormone and cause hyperactivity and learning problems," said lead author Aimin Chen, MD, PhD, assistant professor in the Department of Environmental Health at University of Cincinnati College of Medicine. "Our study adds to several other human studies to highlight the need to reduce exposure to PBDEs in pregnant women."


Dr. Chen and his colleagues collected blood samples from 309 pregnant women enrolled in a study at Cincinnati Children's Hospital Medical Center to measure PBDE levels. They also performed intelligence and behavior tests on the women's children annually until they were 5 years old.


"We found maternal exposure to PBDEs, a group of brominated flame retardants mostly withdrawn from the U.S. market in 2004, was associated with deficits in child cognition at age 5 years and hyperactivity at ages 2-5 years," Dr. Chen said. A 10-fold increase in maternal PBDEs was associated with about a 4 point IQ deficit in 5-year-old children.


Even though PBDEs, except Deca-BDEs, are not used as a flame retardant in the United States anymore, they are found on many consumer products bought several years ago. In addition, the chemicals are not easily biodegradable, so they remain in human tissues and are transferred to the developing fetus.


"Because PBDEs exist in the home and office environment as they are contained in old furniture, carpet pads, foams and electronics, the study raises further concern about their toxicity in developing children," Dr. Chen concluded.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pregnancy / obstetrics section for the latest news on this subject. To view the abstract, "Cognitive Deficits and Behavior Problems in Children with Prenatal PBDE Exposure," go to http://www.abstracts2view.com/pas/view.php?nu=PAS13L1_3550.8.

American Academy of Pediatrics

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Monday, 13 May 2013

Larger Babies Are At A Greater Risk Of Autism

Babies who are above average in size when they are born are at a greater risk of autism, as well as those who are born below average in size, according to the biggest study of fetal growth and autism to date.

The findings, published in The American Journal of Psychiatry, show the first clear link between large babies at birth and the risk of Autism Spectrum Disorder.


The study was led by researchers from the University of Manchester, England, and supports prior research that suggests that premature and poorly grown, low weight infants are at a higher risk for the disorder.


A study by Northwestern University conducted last year suggested that birth weight is an environmental factor contributing to the risk of autism


Autism is a condition that influences how people communicate with others, and there is no known cure. According to the CDC (Centers for Disease Control and Prevention), 1 in every 50 kids in the USA has an autism spectrum disorder. Approximately 1% of all children in the UK have this disorder, according to NHS (National Health Service) figures. Researchers think it is a consequence of environmental and genetic factors.


Professor Kathryn Abel, from the University's Centre for Women's Mental Health and Institute of Brain, Behaviour and Mental Health, and lead researcher explained:


"The processes that leads to ASD probably begin during fetal life; signs of the disorder can occur as early as three years of age. Fetal growth is influenced by genetic and non-genetic factors. A detailed understanding of how fetal growth is controlled and the ways in which it is associated with ASD are therefore important if we are to advance the search for cures.

To our knowledge, this is the first large prospective population-based study to describe the association between the degree of deviance in fetal growth from the normal average in a population of children and risk of ASD with and without intellectual disability. We have shown for the first time categorically that abnormal fetal growth in both directions increases risk of autism spectrum disorder."


The investigators examined data from the Stockholm Youth Cohort in Sweden, where early ultrasound data provide detailed weights of the baby's development in pregnancy. Children and babies also participate in clinical analyses of their motor, language, social, and cognitive skills.


The cohort included records of 589,114 kids aged 0 to 17 years in Sweden between 2001 and 2007. The researchers eliminated data that consisted of children too young to have an ASD, adopted kids, non Swedish or Stockholm County residents, children not born in Sweden, as well as twins.


With the available left over data, the investigators found 4,283 young people with autism and 36,588 without autism who acted as controls.


Study results showed that among the larger babies, i.e. those who were born weighing more than 4.5kg (9 lbs. 14 oz), autism prevalence was higher - the same pattern was seen in smaller infants who were born weighing less than 2.5kg (5.5 lbs.).


The authors found that: Babies with poor fetal growth (very light babies at birth) were 63% more likely to be diagnosed with an ASD later onVery large newborns were 60% more likely to be diagnosed later on with an ASDProfessor Abel added:

"We think that this increase in risk associated with extreme abnormal growth of the fetus shows that something is going wrong during development, possibly with the function of the placenta.

Anything which encourages abnormalities of development and growth is likely to also affect development of the baby's brain. Risk appeared particularly high in those babies where they were growing poorly and continued in utero until after 40 weeks. This may be because these infants were exposed the longest to unhealthy conditions within the mother's womb."


The authors suggest further research be conducted on fetal growth and how it is controlled by the placenta, and how this impacts development of the brain.


They pointed out that the current study was also one of a kind, because it examined the differences between kids who developed ASD with and those without intellectual disability in addition to children born before and after the 40 week mark.


A study released last week by the Yale School of Medicine suggested that a newborn's placenta can predict his or her risk for autism. Placentas with abnormal folds or cell growths can increase the risk for autism.


Written by Kelly Fitzgerald
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our autism section for the latest news on this subject. "Deviance in Fetal Growth and Risk of Autism Spectrum Disorder"
Kathryn M. Abel, M.D., Ph.D.; Christina Dalman, M.D., Ph.D.; Anna C. Svensson, M.Sc., Ph.D.; Ezra Susser, M.D., Dr.P.H.; Henrik Dal, M.Sc.; Selma Idring, M.D.; Roger T. Webb, M.Sc., Ph.D.; Dheeraj Rai, M.B.B.S., M.R.C.Psych.; Cecilia Magnusson, M.D., Ph.D.
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Flame-Retardant Chemicals Could Be Toxic to Kids

News Picture: Flame-Retardant Chemicals Could Be Toxic to Kids

MONDAY, May 6 (HealthDay News) -- Exposure to flame-retardant chemicals in the womb is associated with hyperactivity and lower intelligence in children, a new study indicates.

Researchers examined the effects of polybrominated diphenyl ethers (PBDEs), which were used for decades as fire retardants in common products such as carpeting, baby strollers and electronics.

"In animal studies, PBDEs can disrupt thyroid hormone and cause hyperactivity and learning problems. Our study adds to several other human studies to highlight the need to reduce exposure to PBDEs in pregnant women," study author Dr. Aimin Chen, an assistant professor in the department of environmental health at the University of Cincinnati College of Medicine, said in an American Academy of Pediatrics news release.

The researchers looked at PBDE levels in blood samples from 309 pregnant women and then performed intelligence and behavior tests on the women's children each year until they were 5.

They found that PBDE exposure in the womb was associated with hyperactivity at ages 2 to 5, and with lower intelligence at age 5. A tenfold increase in PBDE exposure during pregnancy was related to about a four-point IQ deficit in 5-year-old children.

While the study tied PBDE exposure during pregnancy to later hyperactivity and lower intelligence, it did not prove a cause-and-effect relationship.

The study was to be presented Monday at the Pediatric Academic Societies annual meeting in Washington, D.C.

PBDEs were mostly withdrawn from the U.S. market in 2004, but they are present in many consumer products bought several years ago and still widely used by Americans, according to the news release. In addition, PBDEs remain in human tissue for a long time and a pregnant woman can transfer them to her fetus.

"Because PBDEs exist in the home and office environment as they are contained in old furniture, carpet pads, foams and electronics, the study raises further concern about their toxicity in developing children," Chen concluded.

Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

-- Robert Preidt MedicalNews
Copyright © 2013 HealthDay. All rights reserved. SOURCE: American Academy of Pediatrics, news release, May 6, 2013



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Health Tip: Taking a Birthing Class

(HealthDay News) -- Taking a birthing class can offer expectant parents peace of mind and help them prepare for the birth of their baby.

The womenshealth.gov website offers these suggestions for parents-to-be:

Check out a local hospital or birthing center to see if they offer birthing classes.Sign up for a birthing class several months before your due date, as they tend to fill up quickly.Make sure the instructors are qualified.Consider bringing to the class the support person who will be with you during labor, whether it's your partner, sibling or friend.In class, you will learn about strategies to help you during labor, early signs of labor and how to control pain.

-- Diana Kohnle MedicalNews
Copyright © 2013 HealthDay. All rights reserved.



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Ultrasound Best Detector of Dangerous Ectopic Pregnancies, Study Finds

News Picture: Ultrasound Best Detector of Dangerous Ectopic Pregnancies, Study Finds

TUESDAY, April 23 (HealthDay News) -- Ectopic pregnancy, in which the fertilized egg grows in the fallopian tubes or other spots outside the uterus, typically leads to miscarriage and can even prove fatal.

Now, a review of the data finds that taking a patient's history along with a clinical exam is not enough to diagnose the condition in women with abdominal pain or vaginal bleeding during early pregnancy.

Instead, the researchers concluded that transvaginal ultrasound is the single best way to evaluate suspected ectopic pregnancy. These scans examine a woman's reproductive organs, including the uterus, ovaries, cervix and vagina.

One expert not connected to the study said detecting ectopic pregnancy early on is crucial.

"Risks from this complication include hemorrhage from rupture, death, and loss of the [fallopian] tube, either from rupture or surgical removal," said Dr. Kecia Gaither, vice chair of obstetrics & gynecology and director of maternal-fetal medicine at Brookdale University Hospital and Medical Center, in New York City. "Patients typically present with abdominal pain, spotting and a positive pregnancy test."

Nevertheless, "fewer than half of the women with an ectopic pregnancy have the classically described symptoms of abdominal pain and vaginal bleeding. In fact, these symptoms are more likely to indicate miscarriage," wrote the team of researchers led by Dr. John Crochet of the Center of Reproductive Medicine in Webster, Texas. That means that confirming a diagnosis of ectopic pregnancy is especially important.

For this review, published in the April 24 issue of the Journal of the American Medical Association, the researchers analyzed 14 studies that included a total of more than 12,000 patients.

The study confirms that "the gold standard for diagnosis is an ultrasound," Gaither said. "Depending on the clinical stability of the patient, a laparoscopic surgical procedure or a laparotomy may [also] be required," she added.

"For any patient who is pregnant in the first trimester -- and has not had a sonogram -- who experiences sudden onset of abdominal pain and spotting, it is important to go to the nearest hospital to be evaluated for an ectopic pregnancy," Gaither said. "The trip may be lifesaving."

One other expert agreed.

"Ectopic pregnancy poses such a risk to patients of childbearing age that it should always be considered when a patient is pregnant and has abdominal pain," said Dr. Jennifer Wu, an obstetrician/gynecologist at Lenox Hill Hospital, in New York City. "Good surveillance with early ultrasound and close follow-up ... can significantly lessen risks, which include emergency surgery and transfusion."

According to background information in the review, ectopic pregnancy is the leading cause of pregnancy-related death in the first trimester and causes up to 6 percent of pregnant women's deaths in the early stages of pregnancy.

-- Robert Preidt MedicalNews
Copyright © 2013 HealthDay. All rights reserved. SOURCES: Jennifer Wu, M.D, obstetrician/gynecologist, Lenox Hill Hospital, New York City; Kecia Gaither, M.D, vice chair of obstetrics & gynecology, and director, maternal-fetal Medicine, Brookdale University Hospital and Medical Center, New York City; Journal of the American Medical Association, news release, April 23, 2013



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Valproate Migraine Drugs During Pregnancy Bad For Baby's IQ

Using migraine prevention valproate sodium drugs during pregnancy can cause offspring to have a lower IQ, the US Food and Drug Administration (FDA) warned yesterday.

Sodium valproate is an anticonvulsant prescribed by doctors for the treatment of migraine, bipolar disorder, PTSD (post-traumatic stress disorder), anxiety disorder, anorexia nervosa and epilepsy.


The FDA is contraindicating valproate drugs for the prevention of migraine headaches for pregnant women. Contraindicated means it should never be used.


Examples of valproate products include: Valproate sodium - DepaconDivalproex sodium - Depakote, Depakote CP, and Depakote ERValproic acid - Depakene and StavzorPlus all related genetic productsDrugs with valproate in them already have a boxed warning for birth defects. The NEAD (Neurodevelopmental Effects of Antiepileptic Drugs) study identified a further risk - that valproate medications can lower the baby's IQ if taken during pregnancy. The link to lower IQ was, in fact, mentioned several years ago (see below). The NEAD study followed over 300 children in the USA and UK who were born to mothers with epilepsy who were taking any of the following antiepileptic drugs - valproate, phenytoin, lamotrigine, or carbamazepine. Enrollment began in 1999 and took place at 25 centers in the USA and UK. The researchers published initial findings in April 2009 in NEJM (New England Journal of Medicine linking valproate usage during pregnancy to lower IQ in offspring.

Russell Katz, M.D., director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research, said yesterday:


"Valproate medications should never be used in pregnant women for the prevention of migraine headaches because we have even more data now that show the risks to the children outweigh any treatment benefits for this use."

As far as pregnant patients with bipolar disorder are concerned, the FDA says that valproate medications should only be considered if other drugs have failed to control symptoms or are otherwise unacceptable.

The FDA wrote in an online communiqué:
"Women who can become pregnant should not use valproate unless it is essential to managing their medical condition."

If you are pregnant, or have just become pregnant and are on a valproate drug, talk to your doctor immediately, the FDA advises. Do not stop taking your medication without checking with a health professional first. Stopping treatment abruptly can cause serious and even life-threatening complications for both the mother and the developing fetus/embryo.


If you are of childbearing age and sexually active and take a valproate product, you should use effective birth control.


Experts do not know when exactly during pregnancy valproate exposure can cause a lowering of IQ in the fetus. In the NEAD study, the mothers were exposed to antiepileptic medications throughout their pregnancies.


These new recommendations come after FDA experts examined the final results of the NEAD study, which showed that at the age of 6 years children whose mothers had taken valproate drugs for epilepsy while pregnant had lower IQs compared to mothers who took the other drug for epilepsy. There was a difference of between 8 and 11 points in the children's IQ, depending on the antiepileptic drug.


Valproate drug labels were updated in 2011 when the FDA released interim results of the NEAD study which showed a reduction in the IQs of children aged 3.


The FDA says it is liaising with drug manufacturers to make changes to the drug labels to reflect these new data and "to change the pregnancy category for prevention of migraine headaches to category X (the drug's risks outweigh the drug's benefits for this use) from category D (the drug's benefits outweigh the drug's risks for this use)".

Researchers from Aarhus University Hospital, Aarhus, Denmark, reported in JAMA (Journal of the American Medical Association), April 2013 issue, that pregnant women who take valproate raise the risk of giving birth to a child with autism.

The authors added "..the absolute risk of autism spectrum disorder was less than 5 percent, which is important to take into account when counseling women about the use of valproate in pregnancy."

Written by Christian Nordqvist
Copyright: Medical News Today
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